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Most multivariate models find advanced age, antibiotic use, co-morbidities, and longer hospital stays are independently predictive of CDI (211,214,232).
Although several studies have not shown an association with proton pump inhibitors (PPIs) and CDI, many other studies have found an association (235,236). In a prospective study of 209 patients with recurrent CDI, logistic regression revealed only two significant independent risk factors for CDI recurrence: increased age and a lower quality of health at enrollment (238).
One meta-analysis of 12 studies totaling 1,382 patients with recurrent CDI and found risk factors for recurrent CDI that included continued use of non- C.