Binare optionen studie von charts lesen
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Alzheimer's is a devastating disease whose incidence is clearly on the rise in America. Fortunately, a binare optionen studie von charts lesen number of binare optionen studie von charts lesen dollars are currently being spent to try to understand what causes Alzheimer's. ApoE-4, a particular allele of the apolipoprotein apoE, is a known risk factor. Since apoE plays a critical role in the transport of cholesterol and fats to the brain, it can be hypothesized that insufficient fat and cholesterol in the brain play a critical role in the disease process.
In parallel, it is becoming very clear that cholesterol is pervasive in the brain, and that it plays a critical role both in nerve transport in the synapse and in maintaining the health of the myelin sheath coating nerve fibers. An extremely high-fat ketogenic diet has been found to improve cognitive ability in Alzheimer's patients.
These and other observations described below lead me to conclude that both a low-fat diet and statin drug treatment increase susceptibility to Alzheimer's. Alzheimer's is a devastating disease that takes away the mind bit by bit over a period of decades. It begins as odd memory gaps but then steadily erodes your life to the point where around-the-clock care is the only option.
With severe Alzheimer's, you can easily wander off and get lost, and may not even recognize your own daughter. Alzheimer's was a little known disease beforebut today it threatens to completely derail the health system in the United States. Currently, over 5 million people in America have Alzheimer's. On average, a person over 65 with Alzheimer's costs three times as much for health care as one without Alzheimer's. More alarmingly, the incidence of Alzheimer's is on the rise. Murray Waldman has studied epidemiological data comparing Alzheimer's with femur fractures, looking back over the last fifty years .
Alarmingly, he has found that, while the incidence of femur fractures another condition which typically increases with age has gone up only at a linear rate, the increase in the incidence of Alzheimer's has gone up exponentially, between and Alzheimer's Epidemic . This increase goes far beyond people living longer: Finally, it's likely these are under-estimates, as many people suffering with Alzheimer's ultimately die of something else. You likely have a close friend or relative who is suffering from Alzheimer's.
Something in our current lifestyle is increasing the likelihood that we will succumb to Alzheimer's. My belief is that two major contributors are our current obsession with low-fat diet, combined with the ever expanding use of statin drugs. I have argued elsewhere that low-fat diet may be a major factor in the alarming increase in autism and adhd in children.
I have binare optionen studie von charts lesen argued that the obesity epidemic and the associated metabolic syndrome can be traced to excessive low-fat diet. Statins are likely contributing to an increase in many serious health issues besides Alzheimer's, such as sepsis, heart failure, fetal damage, and cancer, as I have argued here.
I believe the trends will only get worse in the future, unless we substantially alter our current view of "healthy living. The ideas developed in this essay are the result of extensive on-line research I conducted to try to understand the process by which Alzheimer's develops.
Fortunately, a great deal of research money is currently being spent on Alzheimer's, but a clearly binare optionen studie von charts lesen cause is still elusive. However, many exciting leads are fresh off the press, and the puzzle pieces are beginning to assemble themselves into a coherent story. Researchers are only recently discovering that both fat and cholesterol are severly deficient in the Alzheimer's brain.
It turns out that fat and cholesterol are both vital nutrients in the brain. Cholesterol is essential both in transmitting nerve signals and in fighting off infections. A crucial piece of the puzzle is a genetic marker that predisposes people to Alzheimer's, binare optionen studie von charts lesen "apoE There are currently five known distinct variants of apoE properly termed "alleles"with the ones labelled "2", "3" and "4" being the most prevalent.
A person with apoE-4 allele inherited from both their mother and their father has up to a twenty-fold increased likelihood of developing Alzheimer's disease. Although I have tried to write this essay in a way that is accessible to the non-expert, it will still be helpful to first familiarize you with basic knowledge of the structure of the brain and the roles played by different cell types within the brain. At the simplest level, the brain can be characterized as consisting of two major components: The gray matter comprises binare optionen studie von charts lesen bodies of the neurons, including the cell nucleus, and the white matter contains the myriad of "wires" that connect each neuron to every other neuron it communicates with.
The wires are known as "axons" and they can be quite long, connecting, for example, neurons in the frontal cortex above the eyes with other neurons deep in the interior of the brain concerned with memory and movement. The axons will figure prominently in the discussions below, because they are coated with a fatty substance called the myelin sheath, and this insulating layer is known to be defective in Alzheimer's. Neurons pick up signals transmitted through the axons at junctures known as synapses.
Here the message needs to be transmitted from one neuron to another one, and various neurotransmitters such as dopamine and GABA exert excitatory or inhibitory influences on signal strength. In adidtion to a single axon, neurons typically have several much shorter nerve fibers called dendrites, whose job is to receive incoming signals from diverse sources.
At a given point in time, signals received from multiple sources are integrated in the cell body and a decision is made as to whether the accumulated signal strength is above threshold, in which case the neuron responds by firing a sequence of electrical pulses, which are then transmitted through the axon to a possibly distant destination.
In addition to the neurons, the brain also contains a large number of "helper" cells called glial cells, which are concerned with the care and feeding of neurons. Three principle types of glial cells will play a role in our later discussion: Microglia are the equivalent of white blood cells in the rest of the body. They are concerned with fighting off infective agents such as bacteria and viruses, and they also monitor neuron health, making life-and-death decisions: The astrocytes figure very prominently in our story below.
They nestle up against the neurons and are responsible for assuring an adequate supply of nutrients. Studies on neuron cultures from rodent central nervous systems have shown that neurons depend upon astrocytes for their supply of cholesterol . Neurons critically need cholesterol, both in the synapse  and in the myelin sheath , in order to successfully transmit their signals, and also as a first line of defense against invasive microbes.
Cholesterol is so important to the brain that astrocytes are able to synthesize it from basic ingredients, a skill not found in most cell types.
They also supply the neurons with fatty acids, and they are able to take in short chain fatty acids and combine them to form the longer-chain types of fatty acids that are especially prominent in the brain , and then deliver them to neighboring neurons and to the cerebrospinal fluid.
The third type of glial cell is the oligodendrocyte. These cells specialize in making sure the myelin sheath is healthy. Oligodentrocytes synthesize a special sulfur-containing fatty binare optionen studie von charts lesen, known as sulfatide, from other fatty acids supplied to them by binare optionen studie von charts lesen cerebrospinal fluid .
Sulfatide has been shown to be essential for the maintenance of the myelin sheath. Children born with a defect in the ability to metabolize sulfatide suffer from progressive demyelination, and rapid loss of motor and cognitive functions, resulting in an early death before the age of 5 .
Depletion in sulfatide is a well-known characterization of Alzheimer's, even in early stages before it has been manifested as cognitive decline . And ApoE has been shown to play a crucial role in the maintenance of sulfatide .
Throughout a person's life, the myelin sheath has to be constantly maintained and repaired. This is something that researchers are only beginning to appreciate, but two related properties of Alzheimer's are poor quality myelin sheath alongside a drastically reduced concentration of fatty acids and cholesterol in the cerebrospinal fluid . In addition to some knowledge about the brain, you will also need to know something about the processes that deliver fats and cholesterol to all the tissues of the body, with a special focus on the brain.
Most cell types can use either fats or glucose a simple sugar derived from binare optionen studie von charts lesen as a fuel source to satisfy their energy needs. However, the brain is the one huge exception to this rule. All cells in the brain, both the neurons and the glial cells, are unable to utilize fats for fuel. This is likely because fats are too precious to the brain.
The myelin sheath requires a constant supply of high quality fat to insulate and protect the enclosed axons. Since the brain needs its fats to survive long-term, it is paramount to protect them from oxidation by exposure to binare optionen studie von charts lesen and from attack by invasive microbes. Fats come in all kinds of shapes and sizes. One dimension is the degree of saturation, which concerns how many double bonds they possess, with saturated fats possessing none, monounsaturated fats having only one, and polyunsaturated fats having two or more.
Oxygen breaks the double bond and leaves the fat oxidized, which is problematic for the brain. Polyunsaturated fats are thus the most vulnerable to oxygen exposure, because of multiple double bonds. Fats are digested in the intestine and released into the blood stream in the form of a relatively large ball with a protective protein coat, called a chylomicron.
The chylomicron can directly provide fuel to many cell types, but it may also be sent to the liver where the contained fats are sorted out and redistributed into much smaller particles, which also contain substantial amounts of cholesterol.
These binare optionen studie von charts lesen are called "lipoproteins," henceforth, LPP's because they contain protein in the spherical shell and lipids fats in the interior. If you think these are two different kinds of cholesterol, you would be mistaken. They are just two different kinds of containers for cholesterol and fats that serve different roles in the body. In this essay I will refer to these collectively as the XDL's.
As if this weren't confusing enough, there is also another unique XDL that is found only in the cerebrospinal fluid, that supplies the nutritional needs of the brain and nervous system. An important point about all the XDL's is that they contain distinctly different compositions, and each is targeted programmed for specific tissues. A set of proteins called "apolipoproteins" or, equivalently, "apoproteins" "apo's" for short figure strongly in controlling who gets what.
As you can see from the schematic of the chylomicron shown at the right, it contains a rainbow binare optionen studie von charts lesen different apo's for every conceivable application. The only apo that is of concern to us in the context of this essay is apoE. ApoE is very important to our story because of its known link with Alzheimer's disease. ApoE is a protein, i. Certain alterations in the DNA code lead to defects in the ability of the transcribed protein to perform its biological roles.
ApoE-4, the allele associated with increased risk to Alzheimer's, is presumably unable to perform its tasks as efficiently as the other alleles. By understanding what apoE does, we can better infer how the consequences of doing it poorly might impact the brain, and then observe experimentally whether the features of the Alzheimer's brain are consistent with the roles played by apoE.
A strong clue about apoE's roles can be deduced from where it is found. Only selected cell types can synthesize it, the two most significant of which for our purposes are the liver and the astrocytes in the brain. Thus the astrocytes provide the linkage between the blood and the cerebrospinal fluid. They can usher lipids and cholesterol across the blood-brain barrier, via the special key which is apoE. It turns out that, although apoE is not found in LDL, it does bind to LDL, and this means that astrocytes can unlock the key to LDL in the same way that they can gain access to IDL, and hence the cholesterol and fatty acid contents of LDL are accessible to astrocytes as well, as long as apoE is binare optionen studie von charts lesen properly.
The astrocytes reshape and repackage the lipids and release them into the cerebospinal fluid, both as B-HDL and simply as free fatty acids, available for uptake by all parts of the brain and nervous system . One of the critical reshaping steps is to convert the fats into types that are more attractive to the brain. To understand this process you need to know about another dimension of fats besides their degree of saturation, which is their total length.
Fats have a chain of linked carbon atoms as their spine, and the total number of carbons in a binare optionen studie von charts lesen fat characterizes it as short, medium length, or long. The brain works best when the binare optionen studie von charts lesen fats are long, and, indeed, the astrocytes are able to take in short chain fats and reorganize them to make longer chain fats .